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Professor Alasdair Gray

Director of EMERGE & Consultant in Emergency Medicine

Research Interests:
Emergency Medicine
Qualifications:
MBCHB, FRCS, FCEM, MD
Twitter:
@emerge_research
Professor Alasdair Gray

Professor Gray is interested in the delivery of randomised trials and clinical decision rules in emergency medicine especially related to medical emergencies (chest pain, acute heart failure syndromes, transient loss of consciousness, asthma, atrial fibrillation).

Specifically, he is Chief Investigator for the Rapid-CTCA Study looking at the role of multidetector computed tomography coronary angiography in emergency department patients with suspected acute coronary syndrome. He was previously the Chief Investigator for the 30 centred, 1100 patient emergency department trial of use of noninvasive ventilation in acute heart failure – the 3CPO trial.

Dr Gray is a co-author of over a 100 publications.


Key publications (2008 – present):

  1. A Gray, S Goodacre, D Newby, M Masson, F Sampson and J Nicholl on behalf of the 3CPO triallists. Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema. New England Journal of Medicine. (2008);359:24-33.
  2. S Goodacre, J Cohen, M Bradburn, A Gray, J Benger, T Coats on behalf of the 3Mg Research Team. The 3Mg Trial: Randomised controlled trial of intravenous or nebulised magnesium sulphate or standard therapy for severe acute asthma. The Lancet Respiratory Medicine. (2013); 1:293 – 300.
  3. DN Bateman, JW Dear, HKR Thanacoody, SHL Thomas, M Eddleston, EA Sandilands, J Coyle, JG Cooper, A Rodriguez, I Butcher, SC Lewis, AD Vliegenthart, A Veiraiah, DJ Webb, A Gray. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. The Lancet (2014);22:697-704.
  4. ASV Shah, M Griffiths, KK Lee, DA McAllister, AL Hunter, A Cruikshank, Alan Reid, M Stoddart, F Strachan, S Walker, PO Collinson, FS Apple, AJ Gray, KAA Fox, DE Newby and NL Mills. High-sensitivity cardiac troponin and the under diagnosis of myocardial infarction in women: a prospective cohort study. BMJ. (2015);350:g7873.
  5. Vipul Jairath, BC Kahan, A Gray, CJ Doré, A Mora, MW James, AJ Stanley, SM Everett, AA Bailey, H Dallal, J Greenaway, I Le Jeune, M Darwent, N Church, I Reckless, R Hodge, C Dyer, S Meredith, C Llewelyn, KR Palmer, RF Logan, SP Travis, TS Walsh, MF Murphy on behalf of TRIGGER investigators. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): pragmatic cluster randomised feasibility trial. The Lancet. (2015);epub

Grants

  1. The ESCAPE trial: Randomised Controlled Trial of Chest Pain Assessment Units in UK Emergency Departments. Lead investigator: Steve Goodacre. SDO programme, DOH. £584,000 (2003-2007). Co-applicant, trial management group.
  2. The 3CPO trial: A randomised trial of BiPAP or CPAP non-invasive ventilation compared to standard therapy alone in the management of acute cardiogenic pulmonary oedema. HTA programme, DOH. £1,100,952 (2003-2008). Lead applicant and investigator, trial management group, trial steering group, and writing committee.
  3. Investigation of alveolar epithelial injury and inflammation in acute cardiogenic pulmonary oedema. Lead investigator: Gareth Clegg. CSO programme. £198,633 (2004-2009). Co-applicant, co-investigator.
  4. The RATPAC trial: Randomised Assessment of Treatment using Panel Assay of Cardiac markers. Lead investigator: S Goodacre. HTA programme, DOH. £742,900 (2007-2009). Co-applicant, co-investigator, trial management group, and writing committee.
  1. M Reed. Scottish Clinical Academic Training Fellowship Scheme; Chief Scientist Office, Scottish Executive Health Department. Risk stratification of syncope in the Emergency department: the ROSE study. £129,566 (2007-2009). Principal supervisor.
  2. The 3MG trial: Randomised controlled trial of intravenous or nebulised magnesium sulphate or standard therapy for acute severe asthma. Lead investigator: S Goodacre. HTA programme, DOH £1,727,163 (2007-2012). Co-applicant, co-investigator, trial management group, trial steering committee and writing committee.
  3. Scottish and Newcastle Antiemetic Pre-treatment for Paracetamol Poisoning (SNAP) trial. Lead investigator: N Bateman. CSO programme. £228,850 (2010-2013). Co-applicant, co-investigator, trial management group, writing committee.
  4. A multi-centre, feasibility, cluster randomised controlled trial comparing restrictive versus liberal blood transfusion strategies in patients admitted with Acute Upper Gastrointestinal Bleeding (TRIGGER trial). Lead investigator: M Murphy. NHS Blood and Transplant; Research and Development Programme. £186,035 (2011-2013). Co-applicant, co-investigator, trial management group, writing committee.
  5. Development and validation of the 4AT: a new rapid screening tool for delirium. Lead investigator: Alasdair MacLullich. HTA programme, DOH ££827,431 (2014-2016). Co-applicant.
  6. The Role of Multidetector Computed Tomography Coronary Angiography In Emergency Department Patients With Suspected Acute Coronary Syndrome. A Gray, C Robottom, S Goodacre, D Newby, J Smith, S Lewis, A Fletcher, R Storey, P Thokala. HTA programme, DOH £2,050,000. HTA programme (2014- 2019). Lead Investigator.

 


Trials

HighSTEACS Bioresource

Evaluating the kinetics of cardiac biomarkers after ST-segment Elevation myocardial infarction

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HighSTEACS Bioresource

SALI Study

This is a study looking at incidence and risk factors for poor ankle functional recovery, and the development and progression of post-traumatic ankle osteoarthritis after significant ankle ligament injury.

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SALI Study

SALI study - Significant Ankle Ligament Injury

POEM

An investigation into the Prescription of Analgesia in Emergency Medicine (POEM).

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POEM

Prescription of Analgesia in Emergency Medicine (POEM)

TRIGGER

Evaluating the feasibility and safety of implementing a restrictive versus liberal red blood cell (RBC) transfusion policy.

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TRIGGER

Transfusion in Gastrointestinal Bleeding

3CPO

Continuous positive airway pressure vs non invasive ventilation vs standard therapy for acute pulmonary odema

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3CPO

3MG

Assessing the effectiveness of IV and nebulised magnesium sulphate in the treatment of acute severe asthma.

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3MG

Intravenous or nebulised magnesium sulphate versus placebo for acute severe asthma.

RATPAC

Randomised Assessment of Treatment using Panel Assay of Cardiac markers - a trial of rapid blood testing for acute chest pain in six NHS hospitals around the UK.

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RATPAC

Assesing rapid blood testing for acute chest pain

SNAP

Assesing the effectiveness ondansetron at reducing nausea and vomiting in patients treated with regimen for paracetamol poisoning

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SNAP

Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study

HighSTEACS

A randomised controlled trial assessing patient outcomes before and after the implementation of high sensitivity Troponin assay

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HighSTEACS

Assessing the implementation of high sensitivity Troponin assay

RAPID-CTCA

Evaluating the role of early CT Coronary Angiography on patients with suspected or confirmed Acute Coronary Syndrome.

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RAPID-CTCA

Evaluating the role of early CT Coronary Angiography

Relax 2

Evaluating the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients (CRLXA).

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Relax 2

Evaluating Serelaxin in acute heart failure patients

Related Team

Dr Matt Reed

Dr Matt Reed

Consultant and NRS Career Research Fellow in Emergency Medicine

Related news

Prescription Of analgesia in Emergency Medicine- Now Open for Recruitment

Prescription Of analgesia in Emergency Medicine- Now Open for Recruitment

9 May 2016 | Mia Paderanga

We are very excited to announce that POEM has begun recruitment in the ED. This is a study led by the Royal Berkshire NHS Foundation Trust involving multiple hospitals across the UK. Professor Alasdair Gray is the Principal Investigator for the Royal Infirmary of Edinburgh site.

Read more
#WhyWeDoResearch

#WhyWeDoResearch

15 Apr 2015 | Miranda Odam

We asked a number of colleagues and friends why we do what we do. Their answers are inspiring, challenging and sometimes very funny.

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