Toggle menu

Rachel O’Brien

Lead Research Nurse

Research Interests:
Emergency Medicine, Cardiovascular, Pre-hospital care
Qualifications:
Bachelor in Arts (Human Resource Management & Marketing), Bachelor of Nursing
Twitter:
@emerge_research
Rachel O’Brien

Rachel joined EMERGE in 2012 on a one day a week contract but after catching the research bug managed to convince the team to take her on full time at the beginning of 2015.

Her clinical background is in emergency nursing following a brief stint in orthopaedics. She has worked across a variety of studies building up her research experience and has also spent time working with the resuscitation Research Group.

Rachel enjoys the chaotic yet exciting world of emergency medicine and the challenges and opportunities that a research role brings and loves working with the EMERGE team.

She is now the Lead Research Nurse for the NIHR HTA Funded UK-wide RAPID-CTCA Trial.


Poster Presentations

  • NHS Lothian R&D Conference – March 2015 – Presented
  • RCN International Research Conference – April 2015 – Winner
  • Royal College of Emergency Medicine Conference – September 2015 – Presented
  • Scottish Royal College of Emergency Medicine Conference – May 2015 – Presented
  • NHS Lothian R&D Conference – March 2017 – Presented
  • Royal College of Emergency Medicine Conference- October 2017- Presented
  • NHS Research Conference (NRS) Annual Conference- November 2017- Presented

Trials

KRAKIL Study

People who develop an Acute Kidney Injury (AKI) often have a poor prognosis and many go on to develop chronic kidney disease (CKD). The recognition that AKI and CKD are linked is recent and the molecular pathways that control the transition from acute injury to chronic disease are not well defined. Currently there are no specific treatments that reduce the risk of progressing to CKD after AKI.

Preliminary investigations (not yet published) suggest that AKI causes sustained activation of the endothelin (ET) system to the long-term detriment of renal and systemic haemodynamic function. These pilot data form the basis of our project that seeks to determine whether the ET system is active in patients with AKI and, thus, represents a potential target for therapeutic intervention.

KRAKIL aims to recruit altogether 100 patients from across the emergency department, acute medical unit and inpatient wards at the Royal Infirmary. 50 of which with AKI’s and 50 matched controls with normal kidney function. We will monitor their bloods and urine for 90 days and compare the data from between the two groups.

Read more

KRAKIL Study

TARGET-CTCA Trial

TARGET CTCA is a joint venture between EMERGE and the cardiology research team aiming to recruit patients with suspected ACS across NHS Lothian and NHS Greater Glasgow and Clyde. The study aims to recruit 2270 participants. For further information, please contact the EMERGE team.

Read more

TARGET-CTCA Trial

DASH Trial

DASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.

PRECISE-CTCA Trial

To determine the association between high-sensitivity cardiac troponin concentration and obstructive coronary artery disease in patients presenting to the Emergency Department with suspected acute coronary syndrome and cardiac troponin concentration within the normal reference range using CTCA.

Read more

PRECISE-CTCA Trial

To determine the association between high-sensitivity cardiac troponin concentration and obstructive coronary artery disease in patients presenting to the Emergency Department with suspected acute coronary syndrome and cardiac troponin concentration within the normal reference range using CTCA.

EHA Study

EHA - Epidemiological analysis for the Hereditary Angioedema Disease is an international, multicentre, epidemiological study that aims to explore the feasibility of a new Dried Blood Spot (DBS) filtercard-based screening algorithm and thereby the prevalence of the Hereditary Angioedema.

Read more

EHA Study

EHA - Epidemiological analysis for the Hereditary Angioedema Disease

HU-FIX Trial

Assisting in identifying patients with Humeral shaft fractures in the ED by screening.

Giving patient information sheets to introduce the study, so patient has had adequate time to read and make decision about going into the trial before going to the fracture clinic.

Read more

HU-FIX Trial

Minimal Unit Pricing Study (MUP)

Assessing the impact of the Minimum Unit Pricing

Read more

Minimal Unit Pricing Study (MUP)

Assessing the impact of the Minimum Unit Pricing

SECUre – A Multicentre Survey of the Safety of Emergency Care in UK Emergency Departments

To provide an overview of safety culture and patient safety issues in UK emergency departments, and to determine if there are significant differences between doctors and nurses’ perception of safety issues.

Read more

SECUre – A Multicentre Survey of the Safety of Emergency Care in UK Emergency Departments

SECUre – A Multicentre Survey of the Safety of Emergency Care in UK Emergency Departments

NOVEL Study

Diagnostics devices play an important part in the clinical assessment of a patient’s health and treatment. The purpose of the study is the evaluation of a new diagnostic platform developed by LumiraDx. The evaluation is focused around various biomarkers useful in the emergency settings.

Read more

NOVEL Study

Collection of venous and capillary blood samples for the evaluation of new diagnostic devices for cardiovascular conditions

BRAINED Study

Molecular and cellular analysis of intracranial tumours

Read more

BRAINED Study

Molecular and cellular analysis of intracranial tumours

MAPP2 Study

The Markers and Paracetamol Poisoning Study 2

ATTEST2 Trial

Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2)

Read more

ATTEST2 Trial

Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST 2)

SNAP40 Study

Detection of physiological deterioration by the SNAP40 wearable device compared to standard monitoring devices in the Emergency Department

Read more

SNAP40 Study

Evaluating the role of ambulatory, wireless vital sign monitoring in the detection of deterioration

HighSTEACS Bioresource

Evaluating the kinetics of cardiac biomarkers after ST-segment Elevation myocardial infarction

Read more

HighSTEACS Bioresource

POEM

An investigation into the Prescription of Analgesia in Emergency Medicine (POEM).

Read more

POEM

Prescription of Analgesia in Emergency Medicine (POEM)

IPED Trial

Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope

Read more

IPED Trial

Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope

EMERGE Biobank

The Emergency Medicine Annotated Bioresource Consortium (EM-ABC): A pilot and feasability programme

Read more

EMERGE Biobank

Developing a bioresource for all emergency presentations

Research on Research

Attitudes towards Research and Research Nurses among the clinical team in an Emergency Department (ED) and Acute Medical Unit (AMU)

Read more

Research on Research

Attitudes towards Research and Research Nurses

Time and Motion

To explore the time taken for research nurses to recruit patients in an Emergency Department (ED) setting.

Read more

Time and Motion

Time and Motion

TPTIH

The Pharmacogenetics of Thiazide Induced Hyponatraemia

Read more

TPTIH

The Pharmacogenetics of Thiazide Induced Hyponatraemia

HighSTEACS

A randomised controlled trial assessing patient outcomes before and after the implementation of high sensitivity Troponin assay

Read more

HighSTEACS

Assessing the implementation of high sensitivity Troponin assay

RAPID-CTCA Trial

Evaluating the role of early CT Coronary Angiography on patients with suspected or confirmed Acute Coronary Syndrome.

Read more

RAPID-CTCA Trial

Evaluating the role of early CT Coronary Angiography

Relax 2 Trial

Evaluating the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients (CRLXA).

Read more

Relax 2 Trial

Evaluating Serelaxin in acute heart failure patients

Related news

ED Perceptions of Research

ED Perceptions of Research

8 May 2017 | Rachel O'Brien

A questionnaire was distributed amongst ED staff at the Royal Infirmary of Edinburgh to determine what they thought of research activity in their area.

Read more
Exciting new trial: SNAP40

Exciting new trial: SNAP40

10 Apr 2017 | Megan McGrath

EMERGE will soon begin recruitment to the new SNAP40 trial which will compare the new SNAP40 device with standard monitoring devices in the Emergency Department.

Read more
IPED goes large!

IPED goes large!

17 Jan 2017 | Rachel O'Brien

IPED goes large

Read more
Prescription Of analgesia in Emergency Medicine- Now Open for Recruitment

Prescription Of analgesia in Emergency Medicine- Now Open for Recruitment

9 May 2016 | Mia Paderanga

We are very excited to announce that POEM has begun recruitment in the ED. This is a study led by the Royal Berkshire NHS Foundation Trust involving multiple hospitals across the UK. Professor Alasdair Gray is the Principal Investigator for the Royal Infirmary of Edinburgh site.

Read more
Research –A patient’s Perspective

Research –A patient’s Perspective

26 May 2015 | Polly Black

Meet Hilda. Hilda is 91 and has heart failure. In February 2015 participated in the RELAX 2 study and she kindly shared her experience with us.

Read more
A Day in the Life of a Research Nurse

A Day in the Life of a Research Nurse

26 May 2015 | Jen Simpson

Our very own Jen Simpson, takes us through the roller coaster ride that is 24 hours in the shoes of a Research Nurse.

Read more
#WhyWeDoResearch

#WhyWeDoResearch

15 Apr 2015 | Miranda Odam

We asked a number of colleagues and friends why we do what we do. Their answers are inspiring, challenging and sometimes very funny.

Read more