Toggle menu

3CPO

Start date:
Historic
End date:
April 2007
Co-ordinated by:
NHS Lothian

A randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)

 

Aim

To determine whether non invasive ventilation reduces mortality and whether there are important differences in outcome associated with the method of treatment (CPAP or NIPPV).

Trial Design

Multi centre randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)

List of Publications – references

A Gray, S Goodacre, D Newby, M Masson, F Sampson and J Nicholl on behalf of the 3CPO triallists. Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema. New England Journal of Medicine. (2008);359:24-33.

A Gray, S Goodacre, D Newby, M Masson, F Sampson and J Nicholl on behalf of the 3CPO triallists. Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema. Health Technology Assessment. (2009);13(33).

A Gray, S Goodacre, J Nicholl, M Masson, F Sampson, Mark Elliott, S Crane and DE Newby, on behalf of the 3CPO triallists. A development of a simple risk score to predict early outcome in severe acute cardiogenic pulmonary edema with acidosis: The 3CPO score. Circulation – Heart Failure. (2010);3:111-117.

Chief Investigator

Professor Alasdair Gray

Director of EMERGE & Consultant in Emergency Medicine

Local PI

Professor Alasdair Gray

Director of EMERGE & Consultant in Emergency Medicine

More EMERGE Trials

This trial is a two arm, multicentre parallel group, randomised controlled, open label trial comparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adults.

Read more

EcLiPSE

Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus in Children (EcLiPSE) – an open label randomised controlled trial

The study with PP100-01 in combination with NAC is designed to determine safety and tolerability of PP100-01 when co-administered with NAC as compared to the 12-hr NAC treatment regime for patients that come to the hospital after an overdose of paracetamol/acetaminophen.

Read more

The POP Trial

A Randomised Open Label Exploratory, Safety and Tolerability Study with PP100-01 in Patients Treated with the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose

Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope

Read more

IPED

Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope