Toggle menu

EHA Study

Start date:
January 2019
End date:
December 2022
Co-ordinated by:
Fiona McCurrach
Main trial site:
RIE, Edinburgh

The study will include all participants with angioedema and participants with previous episodes of abdominal pain of no obvious aetiology.

Hereditary Angioedema Disease (HAE) is a rare inherited disorder characterised by recurrent episodes of the accumulation of fluids outside of the blood vessels, blocking the normal flow of blood or lymphatic fluid and causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway.

The diagnosis is complicated because HAE is extremely rare and most physicians typically never see a patient with the disorder. In addition, most cases of angioedema are caused by an allergic reaction.

Gastrointestinal, abdominal tract involvement is an important feature and one of the most common in HAE.  Abdominal attacks may be mistaken for conditions such as appendicitis, cholecystitis, pancreatitis and ischemic bowel. Often, patients can be misdiagnosed as having psychosomatic symptoms and are inappropriately referred for psychiatric evaluation.

The difficulty in recognizing gastrointestinal symptoms as being related to HAE often leads to a delay in diagnosis and to unnecessary surgical procedures.  .

The detection of HAE through blood sampling will permit early diagnosis and disease activity and progression to be assessed at an early stage and thus ultimately permit better treatment.

Chief Investigator

Dr Matt Reed

Director of EMERGE, Consultant, NRS Career Research Fellow & Honorary Reader in Emergency Medicine

Local PI

Dr Matt Reed

Director of EMERGE, Consultant, NRS Career Research Fellow & Honorary Reader in Emergency Medicine

Research Team

Fiona McCurrach

Senior Research Nurse

Julia Grahamslaw

Lead Research Nurse

Emma Moatt

Research Project Manager

Sian Dalgleish

Senior Research Nurse

Claire Cheyne

Research Nurse- Bank Staff

Alison Williams

Senior Research Nurse

Rachel O'Brien

Lead Research Nurse

Clare Moceivei

Senior Research Nurse

Caroline Blackstock

AMU Senior Research Nurse

More EMERGE Trials

Diagnostics devices play an important part in the clinical assessment of a patient’s health and treatment. The purpose of the study is the evaluation of a new diagnostic platform developed by LumiraDx. The evaluation is focused around various biomarkers useful in the emergency settings.

Read more

NOVEL Study

Collection of venous and capillary blood samples for the evaluation of new diagnostic devices for cardiovascular conditions

Prospective multicentre observational study conducted over one calendar month in 2019, with the aim of describing the epidemiology of non-trauma related headache in adults presenting to emergency departments including investigations, treatments and outcome.

This will include adult patients presenting to the ED with non-trauma-related headache as their primary complaint.

Read more

HEAD Study

Global Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real world

Read more

Garfield-VTE Study

Global Anticoagulant Registry In the FIELD – Venous Thromboembolic Events