Randomised Assessment of Treatment using Panel Assay of Cardiac markers – a trial of rapid blood testing for acute chest pain in six NHS hospitals around the UK.
To evaluate the clinical effectiveness and cost-effectiveness of the most promising point-of-care cardiac marker panel currently used in the emergency department.
Multi centre randomised controlled trial of point of care markers vs standard care in patients with acute chest pain in the Emergency Department.
Goodacre SW, Bradburn M, Cross E, et al. The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart 2011;97:190–6.
Fitzgerald P, Goodacre SW, Cross E, Dixon S: Cost-effectiveness of point-of-care biomarker assessment for suspected myocardial infarction: the randomized assessment of treatment using panel Assay of cardiac markers (RATPAC) trial. Acad Emerg Med 2011; 18(5): 488-95.
Bradburn M, Goodacre SW, Fitzgerald P, Coats T, Gray A, Hassan T, Humphrey J, Kendall J, Smith J, Collinson P; RATPAC Research Team: Interhospital variation in the RATPAC trial (Randomised Assessment of Treatment using Panel Assay of Cardiac markers). Emerg Med J 2012; 29(3): 233-8.
Goodacre S, Bradburn M, Fitzgerald P Cross E, Collinson P, Gray A and Hall AS. The RATPAC (Randomised Assessment of Treatment using Panel Assay of Cardiac markers) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Health Technology Assessment. (2011);15(23).
P Collinson, S Goodacre, D Gaze and A Gray. Very Early Diagnosis Of Chest Pain By Point Of Care Testing; Comparison Of The Diagnostic Efficiency Of A Panel Of Cardiac Biomarkers Compared To Troponin Measurement Alone In The Randomised Assessment Of Panel Assay Of Cardiac Markers (RATPAC) Trial. Heart. (2012);98:312-318.
Evaluating the role of early CT Coronary Angiography on patients with suspected or confirmed Acute Coronary Syndrome.
Evaluating the role of early CT Coronary Angiography
Detection of physiological deterioration by the SNAP40 wearable device compared to standard monitoring devices in the Emergency Department
Evaluating the role of ambulatory, wireless vital sign monitoring in the detection of deterioration
The study with PP100-01 in combination with NAC is designed to determine safety and tolerability of PP100-01 when co-administered with NAC as compared to the 12-hr NAC treatment regime for patients that come to the hospital after an overdose of paracetamol/acetaminophen.
A Randomised Open Label Exploratory, Safety and Tolerability Study with PP100-01 in Patients Treated with the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose