Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study
To assess the effectiveness of pre-treatment with ondansetron at reducing nausea and vomiting in patients treated with either the conventional regimen or a modified regimen of acetylcysteine for paracetamol Poisoning
Multi centre randomised controlled trial of ondansetron vs placebo in patients treated with either the conventional regimen or a modified regimen of Acetylcysteine for Paracetamol Poisoning
Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology. 2013 Aug; 58(2):777-87. doi: 10.1002/hep.26294. Epub 2013 Jul 2.
Bateman DN, Dear JW, Carroll R, Pettie J, Yamamoto T, Elamin M, Peart L, Dow M, Coyle J, Gray AJ, Dargan P, Wood DM, Eddleston M, Thomas SHL. Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: The recent United Kingdom experience. Clinical Toxicology (2014) 52 (8), 868-872
Bateman DN, Pettie J, Carroll R, Dow M, Coyle J, Cranfield K, Gray AJ, Hook C, Sandilands E, Veiraiah A, Webb DJ, Dear JW, Eddleston M. Effects of initial acetylcysteine infusion rates on adverse reactions in paracetamol overdose: A cohort study. CLINICAL TOXICOLOGY (2014) 52 (4), 303-303, 2014
Bateman DN, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Cranfield KR, Hook C, Sandilands EA, Veiriaiah A, Webb DJ, Gray A, Dargan PI, Wood DM, Thomas SH, Dear JW, Eddleston M. Effect of the UK’s Revised Paracetamol Poisoning Management Guidelines on Admissions, Adverse Reactions, and Costs of Treatment. Br J Clin Pharmacol. 2014 Mar 26. doi: 10.1111/bcp.12362. [Epub ahead of print]
Bateman DN, Dear JW, Thanacoody HK, Thomas SH, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vliegenthart AD, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet. 2014 Feb 22;383(9918):697-704. doi: 10.1016/S0140-6736(13)62062-0. Epub 2013 Nov 28.
Dear JW, Antoine DJ, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, J Moggs, Bateman DN, Goldring C, Park K. Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital.CLINICAL TOXICOLOGY (2013) 51 (4), 255-255, 2013
Gray AJ, Dear JW, Thanacoody RH, Thomas SH S, Eddleston M, Sandilands E, Coyle J, Cooper J, Rodriguez A, Butcher I, Lewis S, Vliegenthart A, Veiraiah A, Webb DJ, Bateman DN. Reducing adverse effects from intravenous n-acetylcysteine treatment of paracetamol poisoning: principal results of the Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning (SNAP) randomised controlled trial. Emergency Medicine Journal (2013) 30 (10), 867-868
Thanacoody HK, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SH, Bateman DN. Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol. 2013 Apr 4;14:20. doi: 10.1186/2050-6511-14-20.
The Emergency Medicine Annotated Bioresource Consortium (EM-ABC): A pilot and feasability programme
Developing a bioresource for all emergency presentations
Attitudes towards Research and Research Nurses among the clinical team in an Emergency Department (ED) and Acute Medical Unit (AMU)
Attitudes towards Research and Research Nurses
Strokes caused by a clot are described as ischaemic. When patients experience ischaemic strokes they may be eligible for “clot busting” therapy (thrombolysis). Currently thrombolysis has been shown to improve patient outcome after a stroke if administered within the first 4.5 hours after stroke onset. Up to 25% of patients wake up with symptoms of a stroke. This means they have an unknown onset time for their stroke (so called ‘wake up strokes’). With no known onset time, they are ineligible for thrombolysis. This study will investigate how we might determine stroke onset time.