Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study
To assess the effectiveness of pre-treatment with ondansetron at reducing nausea and vomiting in patients treated with either the conventional regimen or a modified regimen of acetylcysteine for paracetamol Poisoning
Multi centre randomised controlled trial of ondansetron vs placebo in patients treated with either the conventional regimen or a modified regimen of Acetylcysteine for Paracetamol Poisoning
Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology. 2013 Aug; 58(2):777-87. doi: 10.1002/hep.26294. Epub 2013 Jul 2.
Bateman DN, Dear JW, Carroll R, Pettie J, Yamamoto T, Elamin M, Peart L, Dow M, Coyle J, Gray AJ, Dargan P, Wood DM, Eddleston M, Thomas SHL. Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: The recent United Kingdom experience. Clinical Toxicology (2014) 52 (8), 868-872
Bateman DN, Pettie J, Carroll R, Dow M, Coyle J, Cranfield K, Gray AJ, Hook C, Sandilands E, Veiraiah A, Webb DJ, Dear JW, Eddleston M. Effects of initial acetylcysteine infusion rates on adverse reactions in paracetamol overdose: A cohort study. CLINICAL TOXICOLOGY (2014) 52 (4), 303-303, 2014
Bateman DN, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Cranfield KR, Hook C, Sandilands EA, Veiriaiah A, Webb DJ, Gray A, Dargan PI, Wood DM, Thomas SH, Dear JW, Eddleston M. Effect of the UK’s Revised Paracetamol Poisoning Management Guidelines on Admissions, Adverse Reactions, and Costs of Treatment. Br J Clin Pharmacol. 2014 Mar 26. doi: 10.1111/bcp.12362. [Epub ahead of print]
Bateman DN, Dear JW, Thanacoody HK, Thomas SH, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vliegenthart AD, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet. 2014 Feb 22;383(9918):697-704. doi: 10.1016/S0140-6736(13)62062-0. Epub 2013 Nov 28.
Dear JW, Antoine DJ, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, J Moggs, Bateman DN, Goldring C, Park K. Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital.CLINICAL TOXICOLOGY (2013) 51 (4), 255-255, 2013
Gray AJ, Dear JW, Thanacoody RH, Thomas SH S, Eddleston M, Sandilands E, Coyle J, Cooper J, Rodriguez A, Butcher I, Lewis S, Vliegenthart A, Veiraiah A, Webb DJ, Bateman DN. Reducing adverse effects from intravenous n-acetylcysteine treatment of paracetamol poisoning: principal results of the Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning (SNAP) randomised controlled trial. Emergency Medicine Journal (2013) 30 (10), 867-868
Thanacoody HK, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SH, Bateman DN. Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol. 2013 Apr 4;14:20. doi: 10.1186/2050-6511-14-20.
1. Ambulatory Device, Rocket Pleural vent insertion
2. Standard Treatment, Aspiration +/- chest drain
Primary Outcome Measures
To assess whether use of an ambulatory device (Rocket Pleural Vent) and treatment strategy reduces hospital stay. Total length of stay in hospital up to 30 days post randomisation. Up to 30 days post randomisation.
RAMPP trial - Randomised Controlled Trial: Pleural vent (rocket) V standard care in Primary Spontaneous Pnuemothorax
Identification and characterization of the clinical toxicology of novel psychoactive substances (NPS) by laboratory analysis of biological samples from recreational drug users.
Identification of Novel Psychoactive Substances (IONA)