Toggle menu

3CPO Trial

Start date:
Historic
End date:
April 2007
Co-ordinated by:
NHS Lothian

A randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)

 

Aim

To determine whether non invasive ventilation reduces mortality and whether there are important differences in outcome associated with the method of treatment (CPAP or NIPPV).

Trial Design

Multi centre randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)

List of Publications – references

A Gray, S Goodacre, D Newby, M Masson, F Sampson and J Nicholl on behalf of the 3CPO triallists. Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema. New England Journal of Medicine. (2008);359:24-33.

A Gray, S Goodacre, D Newby, M Masson, F Sampson and J Nicholl on behalf of the 3CPO triallists. Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema. Health Technology Assessment. (2009);13(33).

A Gray, S Goodacre, J Nicholl, M Masson, F Sampson, Mark Elliott, S Crane and DE Newby, on behalf of the 3CPO triallists. A development of a simple risk score to predict early outcome in severe acute cardiogenic pulmonary edema with acidosis: The 3CPO score. Circulation – Heart Failure. (2010);3:111-117.

Chief Investigator

Professor Alasdair Gray

Honorary Professor of Emergency Medicine & Clinical Director of the Emergency Department

Local PI

Professor Alasdair Gray

Honorary Professor of Emergency Medicine & Clinical Director of the Emergency Department

More EMERGE Trials

ISARIC4C – Coronavirus Clinical Characterisation Consortium, an observational study

ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK)

Assisting in identifying patients with Humeral shaft fractures in the ED by screening.

Giving patient information sheets to introduce the study, so patient has had adequate time to read and make decision about going into the trial before going to the fracture clinic.

Read more

HU-FIX Trial

Diagnostics devices play an important part in the clinical assessment of a patient’s health and treatment. The purpose of the study is the evaluation of a new diagnostic platform developed by LumiraDx. The evaluation is focused around various biomarkers useful in the emergency settings.

Read more

NOVEL Study

Collection of venous and capillary blood samples for the evaluation of new diagnostic devices for cardiovascular conditions