Is Rotational Thromboelastometry (ROTEM) useful to detect Occult Coagulopathy in the Emergency Department?
Single-centre, prospective, observational cohort study, conducted in the Emergency Department (ED) of the Royal Infirmary of Edinburgh.
Reed MJ, Nimmo AF, McGee D, Manson L, Neffendorf AE, Moir L, Donaldson LS. Rotational thrombolelastometry produces potentially clinical useful results within 10 min in bleeding Emergency Department patients: the DEUCE study. Eur J Emerg Med. 2013; 20(3): 160-6
Director of EMERGE, Consultant, NRS Career Research Fellow & Honorary Reader in Emergency Medicine
Director of EMERGE, Consultant, NRS Career Research Fellow & Honorary Reader in Emergency Medicine
DASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.
People who develop an Acute Kidney Injury (AKI) often have a poor prognosis and many go on to develop chronic kidney disease (CKD). The recognition that AKI and CKD are linked is recent and the molecular pathways that control the transition from acute injury to chronic disease are not well defined. Currently there are no specific treatments that reduce the risk of progressing to CKD after AKI.
Preliminary investigations (not yet published) suggest that AKI causes sustained activation of the endothelin (ET) system to the long-term detriment of renal and systemic haemodynamic function. These pilot data form the basis of our project that seeks to determine whether the ET system is active in patients with AKI and, thus, represents a potential target for therapeutic intervention.
KRAKIL aims to recruit altogether 100 patients from across the emergency department, acute medical unit and inpatient wards at the Royal Infirmary. 50 of which with AKI’s and 50 matched controls with normal kidney function. We will monitor their bloods and urine for 90 days and compare the data from between the two groups.