LAVAS Study
Start date:Historic End date:
June 2014 Co-ordinated by:
NHS Lothian
Lactate, Arterial and Venous Agreement in Sepsis – LAVAS trial
Aim
To determine whether an agreement between peripheral venous and arterial lactate exists in patients presenting to an Emergency Department with sepsis.
Trial Design
A prospective observational study in a consecutive sample of eligible and consented patients in the Royal Infirmary of Edinburgh
Eligibility criteria (summary)
Patients who present to the Emergency Department with suspected sepsis
Chief Investigator
Dr Deepankar Datta
Specialist Trainee Emergency Medicine
Local PI
Dr Deepankar Datta
Specialist Trainee Emergency Medicine
Research Team
Julia Grahamslaw
Lead Research Nurse
More EMERGE Trials
ISARIC4C – Coronavirus Clinical Characterisation Consortium, an observational study
ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK)
Trauma remains a major cause of mortality and morbidity. 10% of blunt force trauma patients admitted to a major trauma centre will have sustained one or more fractured ribs, which may cause significant pain and problems with breathing.
To establish the outcome of rib fractures and their treatments it is important to know what to measure, and how to measure this accurately. A patient reported outcome measure (PROM) is a questionnaire used to measure patient reported outcomes, to show how the patient is doing from their perspective.
Whilst there is ongoing interest in surgery to fix broken ribs, there is no PROM specifically designed for patients with broken ribs following chest trauma. Therefore, it is not clear whether the symptoms that are most important to these patients are being represented by the current outcome measures. This study aims to create a PROM specific to rib fracture patients to give us a better understanding of whether a new treatment actually makes a difference to the patient’s recovery.
The 1st part of the study involves asking patients with rib fractures to help design a new PROM. This will be conducted through focus groups at a site in Nottingham. The 2nd part of the study entails field testing, whereby patients with rib fractures will be asked to test this new PROM. This will be conducted across multiple secondary care settings in the UK, including the Royal Infirmary of Edinburgh. The study is expected to run for approximately 2 years, with recruitment targets of 50 patients for the PROM Creation phase and 250 for the Field Testing phase.
PROM OCTS
Identification and characterization of the clinical toxicology of novel psychoactive substances (NPS) by laboratory analysis of biological samples from recreational drug users.
IONA Study
Identification of Novel Psychoactive Substances (IONA)