PRECISE-CTCA Trial
Start date:4th December Co-ordinated by:
Rachel O'Brien Main trial site:
RIE
This is a single-centre observational study. All participants will be recruited from the Emergency Department at the Royal Infirmary of Edinburgh and invited for an outpatient CTCA at the Clinical Research Imaging Centre. This study will inform Dr. Lee’s PhD funded as part of a British heart Foundation Fellowship.
Local PI
Dr Ken Lee
Cardiology Research Fellow
Research Team
Rachel O'Brien
Lead Research Nurse
Polly Black
Senior Research Nurse
Julia Grahamslaw
Lead Research Nurse
Clare Moceivei
Research Nurse- Bank Staff
Alison Williams
Senior Research Nurse
Fiona McCurrach
Senior Research Nurse
Caroline Blackstock
AMU Senior Research Nurse
Alison Grant
Senior Research Nurse
Lisa Donald
Research Nurse
Claire Cheyne
Senior Research Nurse
More EMERGE Trials
To determine the association between high-sensitivity cardiac troponin concentration and obstructive coronary artery disease in patients presenting to the Emergency Department with suspected acute coronary syndrome and cardiac troponin concentration within the normal reference range using CTCA.
PRECISE-CTCA Trial
To determine the association between high-sensitivity cardiac troponin concentration and obstructive coronary artery disease in patients presenting to the Emergency Department with suspected acute coronary syndrome and cardiac troponin concentration within the normal reference range using CTCA.
People who develop an Acute Kidney Injury (AKI) often have a poor prognosis and many go on to develop chronic kidney disease (CKD). The recognition that AKI and CKD are linked is recent and the molecular pathways that control the transition from acute injury to chronic disease are not well defined. Currently there are no specific treatments that reduce the risk of progressing to CKD after AKI.
Preliminary investigations (not yet published) suggest that AKI causes sustained activation of the endothelin (ET) system to the long-term detriment of renal and systemic haemodynamic function. These pilot data form the basis of our project that seeks to determine whether the ET system is active in patients with AKI and, thus, represents a potential target for therapeutic intervention.
KRAKIL aims to recruit altogether 100 patients from across the emergency department, acute medical unit and inpatient wards at the Royal Infirmary. 50 of which with AKI’s and 50 matched controls with normal kidney function. We will monitor their bloods and urine for 90 days and compare the data from between the two groups.