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SNAP Trial

Start date:
Historic
End date:
December 2012
Co-ordinated by:
University of Edinburgh and NHS Lothian

Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study

Aim

To assess the effectiveness of pre-treatment with ondansetron at reducing nausea and vomiting in patients treated with either the conventional regimen or a modified regimen of acetylcysteine for paracetamol Poisoning

Trial Design

Multi centre randomised controlled trial of ondansetron vs placebo in patients treated with either the conventional regimen or a modified regimen of Acetylcysteine for Paracetamol Poisoning

List of Publications – references

Antoine DJ, Dear JW, Lewis PS, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, Moggs JG, Bateman DN, Goldring CE, Park BK. Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology. 2013 Aug; 58(2):777-87. doi: 10.1002/hep.26294. Epub 2013 Jul 2.

Bateman DN, Dear JW, Carroll R, Pettie J, Yamamoto T, Elamin M, Peart L, Dow M, Coyle J, Gray AJ, Dargan P, Wood DM, Eddleston M, Thomas SHL. Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: The recent United Kingdom experience. Clinical Toxicology (2014) 52 (8), 868-872

Bateman DN, Pettie J, Carroll R, Dow M, Coyle J, Cranfield K, Gray AJ, Hook C, Sandilands E, Veiraiah A, Webb DJ, Dear JW, Eddleston M. Effects of initial acetylcysteine infusion rates on adverse reactions in paracetamol overdose: A cohort study. CLINICAL TOXICOLOGY (2014) 52 (4), 303-303, 2014

Bateman DN, Carroll R, Pettie J, Yamamoto T, Elamin ME, Peart L, Dow M, Coyle J, Cranfield KR, Hook C, Sandilands EA, Veiriaiah A, Webb DJ, Gray A, Dargan PI, Wood DM, Thomas SH, Dear JW, Eddleston M. Effect of the UK’s Revised Paracetamol Poisoning Management Guidelines on Admissions, Adverse Reactions, and Costs of Treatment. Br J Clin Pharmacol. 2014 Mar 26. doi: 10.1111/bcp.12362. [Epub ahead of print]

Bateman DN, Dear JW, Thanacoody HK, Thomas SH, Eddleston M, Sandilands EA, Coyle J, Cooper JG, Rodriguez A, Butcher I, Lewis SC, Vliegenthart AD, Veiraiah A, Webb DJ, Gray A. Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet. 2014 Feb 22;383(9918):697-704. doi: 10.1016/S0140-6736(13)62062-0. Epub 2013 Nov 28.

Dear JW, Antoine DJ, Starkey-Lewis P, Platt V, Coyle J, Masson M, Thanacoody RH, Gray AJ, Webb DJ, J Moggs, Bateman DN, Goldring C, Park K. Mechanistic biomarkers provide early and sensitive detection of paracetamol-induced acute liver injury at first presentation to hospital.CLINICAL TOXICOLOGY (2013) 51 (4), 255-255, 2013

Gray AJ, Dear JW, Thanacoody RH, Thomas SH S, Eddleston M, Sandilands E, Coyle J, Cooper J, Rodriguez A, Butcher I, Lewis S, Vliegenthart A, Veiraiah A, Webb DJ, Bateman DN. Reducing adverse effects from intravenous n-acetylcysteine treatment of paracetamol poisoning: principal results of the Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning (SNAP) randomised controlled trial. Emergency Medicine Journal (2013) 30 (10), 867-868

Thanacoody HK, Gray A, Dear JW, Coyle J, Sandilands EA, Webb DJ, Lewis S, Eddleston M, Thomas SH, Bateman DN. Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol. 2013 Apr 4;14:20. doi: 10.1186/2050-6511-14-20.

Local PI

Professor Alasdair Gray

Honorary Professor of Emergency Medicine & Clinical Director of the Emergency Department

Research Team

Judy Coyle

Scottish Research Nurse of the Year 2015 (SRNCN)

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