Toggle menu

TRIGGER

Start date:
Historic
End date:
March 2014
Co-ordinated by:
National Health Services Blood and Transplant Services

Transfusion in Gastrointestinal Bleeding

Aim

To evaluate the feasibility and safety of implementing a restrictive versus liberal red blood cell (RBC) transfusion policy in adult patients admitted with Acute Upper Gastrointestinal Bleeding (AUGIB) in order to inform the design of a definitive phase III randomised controlled trial.

Trial Design

A multi-centre, feasibility, cluster randomised controlled trial comparing restrictive versus liberal blood transfusion strategies in adult patients admitted with acute upper gastrointestinal bleeding

Chief Investigator

Professor Mike Murphy & Dr, Vipul Jairath 

Local PI

Professor Alasdair Gray

List of Publications – References

Vipul Jairath, Brennan C Kahan, Alasdair Gray, Caroline J Doré, Ana Mora, Martin W James, Adrian J Stanley, Simon M Everett, Adam A Bailey, Helen Dallal, John Greenaway, Ivan Le Jeune, Melanie Darwent, Nicholas Church, Ian Reckless, Renate Hodge, Claire Dyer, Sarah Meredith, Charlotte Llewelyn, Kelvin R Palmer, Richard F Logan, Simon P Travis, Timothy S Walsh, Michael F Murphy: Restrictive versus liberal blood transfusion for acute uppergastrointestinal bleeding (TRIGGER): a pragmatic, open-label,cluster randomised feasibility trial. The Lancet Published online May 6, 2015

Local PI

Professor Alasdair Gray

Director of EMERGE & Consultant in Emergency Medicine

Research Team

Judy Coyle

Scottish Research Nurse of the Year 2015 (SRNCN)

More EMERGE Trials

This trial is a two arm, multicentre parallel group, randomised controlled, open label trial comparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adults.

Read more

EcLiPSE

Emergency Treatment with Levetiracetam or Phenytoin in Status Epilepticus in Children (EcLiPSE) – an open label randomised controlled trial

Identification and characterization of the clinical toxicology of novel psychoactive substances (NPS) by laboratory analysis of biological samples from recreational drug users.

Read more

IONA

Identification of Novel Psychoactive Substances (IONA)

Patients commonly present to the Emergency Department with epistaxsis (nose bleed). Standard first aid measures such as applying pressure can often stem bleeding however in more severe cases of epistaxsis further treatment is required.

Read more

NoPac

Novel Use of Tranexamic Acid to Reduce the Need for Nasal Packing