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Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ASPIREDMulti-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients
British Heart Foundation Professor Matt ReedCaroline BlackstockOpen to Recruitment
POC-ETPoint of Care Evaluation of high-sensitivity cardiac Troponin (POC-ET) studyBritish Heart FoundationProfessor Nick MillsFiona McCurrachOpen to Recruitment
TARGET-CTCA TrialTroponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography British Heart FoundationProfessor Nick MillsRachel O’BrienClosed - in analysis stage

Stroke and Neurosurgery

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ATTEST2 TrialAlteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis Stroke Association & British Heart FoundationDr William WhitelyAllan MacRaildOpen to Recruitment
BRAIN MATRIXA BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorshipThe Brain Tumour Charity and Genomics EnglandDr Paul BrennanAllan MacRaildOpen to Recruitment
BRAINED- TBIBRAINED – TBIUsing Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain InjuryNIHR Brain Injury MedTech Co-operative Seedcorn Funding CompetitionDr Paul BrennanSarah RisbridgerCompleting Follow Up
Can-SCAHnCan-SCAHnSelective neuroimaging for head-injured emergency patients who take anticoagulant medication.Canadian Institutes of Health ResearchProfessor Matt ReedJulia GrahamslawIn Set Up
CARECavernomas A Randomised Effectiveness (CARE) pilot trial, to address the
effectiveness of active treatment (with neurosurgery or stereotactic
radiosurgery) versus conservative management in people with symptomatic
brain cavernoma
NIHRMr Ioannis FouyasAllan MacRaildOpen to Recruitment
DENSDuration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collarNIHR HTADr Paul Brennan/Professor Matt ReedAnuka BoldbaatarOpen to Recruitment
ENRICH-AFENRICH-AFEdoxabaN foR IntraCranial Hemorrhage survivors with Atrial FibrillationDaiichi Sankyo
Professor Rustam Al-Shahi SalmanAnuka BoldbaatarOpen to Recruitment
IMPACTInternational Post Market Product Surveillance Study of Intracranial Aneurysms Treated
with an Endovascular Approach
STRYKERDr Jonny DownerAllan MacRaildOpen to Recruitment
INFERENCEIdentificatioN oF biomarkErs foR Early diagNosis of CancErInnovate UKDr Paul BrennanSarah RisbridgerCompleting Follow Up
OPTIMASOPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trialBritish Heart FoundationDr Fergus DougalSarah RisbridgerOpen to Recruitment
PreSizeReal-World Performance Evaluation of
PreSize Neurovascular Medical Software
in a Clinical Setting
Oxford HeartbeatDr Jonny DownerSarah RisbridgerOpen to Recruitment
PROHIBIT-ICHPrevention Of Hypertensive Injury to the Brain by Intensive Treatment after
IntraCerebral Haemorrhage: a pilot randomised trial of home telemetry-guidedtreatment
Stroke AssociationNeshika SamarasekeraAllan MacRaildCompleting Follow Up
SEALANTSEALANT: Safety and Effectiveness Analysis of stent assisted coiling with LVIS® Evo™ and HydroCoil® Embolic
System in ANeurysm Treatment
MicroventionDr Jonny DownerAnuka BoldbaatarOpen to Recruitment
Shared Stroke DecisionsShared Stroke DecisionsDevelopment and implementation of Realistic Medicine for severe stroke through Shared Decision MakingEdinburgh and Lothian Health FoundationProfessor Gillian MeadSarah RisbridgerCompleting Follow Up
TREATTrenza Embolization Device for Intrasaccular Aneurysm TreatmentSTRYKERDr Jonny Downer
Allan MacRaildOpen to Recruitment
TRIDENTTriple therapy prevention of Recurrent Intracerebral Disease EveNts TrialNeshika SamarasekeraAllan MacRaildOpen to Recruitment
PhEASTPharyngeal Electrical stimulation for Acute Stroke dysphagia TrialNational Institute of Health Research Health Technology Assessment program Devices supplied by Phagenesis Ltd
Richard O’BrienSarah RisbridgerOpen to Recruitment
Oceanic StrokePhase 3 study to investigate the efficacy and safety of the oral FXIa inhibitor
asundexian (BAY 2433334) compared with placebo in participants after an acute non-cardioembolic ischemic stroke or high-risk TIA
Bayer AGNeil HunterSarah RisbridgerOpen to Recruitment


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
POP2POP2A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol OverdoseEgetis TherapeuticsProfessor James DearJulia Grahamslaw/Caroline BlackstockIn Set Up
HiSNAPThe HiSNAP Trial aims to test conventional (200mg/kg) versus higher (450mg/kg and 600mg/kg) doses of the drug N-Acetylcysteine (known as NAC) which is commonly used to treat the effects of paracetamol overdoseChief Scientist OfficeProfessor James DearAnna MiellIn Set Up
POC-DILIPOC-DILIThe Point-of-care Assessment of Drug-Induced Liver Injury (POC-DILI) Study aims to develop blood testing for liver injury during the early stages of assessment of people who have taken a paracetamol overdose.Medical Research Council (MRC)Professor James DearAnna MiellIn Set Up
TIPSSTIPSSThis trial aims to determine where in the body sulbutiamine/benfotiamine is converted to thiamine.Medical Research Council (MRC) (Confidence in Concept Fund)Professor Michael EddlestonAnna MiellClosed
Thiamine in CSFThiamine in CSFThis study aims to compare several forms of thiamine by testing the absorption into the blood and cerebrospinal fluid (CSF) at different time points after taking a doseProfessor Michael EddlestonAnna MiellOpen to Recruitment

Blood Project Group

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
National Code Red AuditThe aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.SNBTSProfessor Matt ReedProfessor Matt ReedOpen to Recruitment


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
EVISEarly Vasopressors in SepsisDr. Alasdair Corfield
Julia Grahamslaw &Fiona McCurrach Open to Recruitment


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AFiRMAFiRMApplication of Functional Renal MRI to improve assessment of chronic kidney diseaseNational Institute for Health ResearchDr Neeraj DhaunEmily GoddenOpen to Recruitment
KRAKIL StudyKidney Recovery after Acute Kidney Injury – Longitudinal studyMedical Research CouncilProfessor James DearEmily GoddenOpen to Recruitment
OCTOCTAssessment of retinal vasculature using optical coherence tomography in
health, hypertension & kidney disease
Dr Neeraj DhaunEmily GoddenOpen to Recruitment

Trauma, Surgical and Orthopaedics

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
RELIEFThe Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trialNorth Bristol NHS TrustDr. Edward CarltonFiona McCurrachCompleting Follow Up


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
FIDOValidating clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland. Royal College of Emergency Medicine Doctoral FellowshipDr Thomas WaterfieldAshleigh HeganClosed to Recruitment
MASTPharmacological Management of Seizures post Traumatic Brain Injury.NIHRDr Jay ShettyAshleigh HeganOpen to recruitment
BACHbBreathing Assistance in CHildren with bronchiolitis (BACHb): a group-sequential two-stratum multicentre open-label randomised clinical trial of respiratory support in infants with acute bronchiolitisNational Institute of Health ResearchDr David ArmstrongCaroline BlackstockIn Set Up


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
CoSTEDCessation Of Smoking Trial in the Emergency DepartmentNorfolk and Norwich University Hospitals NHS
Foundation Trust (NNUH)
Professor Alasdair GrayAnna MiellCompleting Follow Up

Innovation Studies


LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
NOVEL2 StudyCollection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular ConditionsLumiraDXProfessor Alasdair GrayVictoria MinnisOpen for Recruitment

Medical Wearable Device studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ASPIREDMulti-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patientsBritish Heart FoundationProfessor Matt ReedCaroline BlackstockOpen to Recruitment

Data Projects

Data Science

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
Improving Multi-Morbidity Acute Care Using Data AnalyticsSBRI: Improving Multi-Morbidity Acute Care Using Data AnalyticsHealth Innovation South East Scotland / Innovate UKNaz Lone/Professor Matt ReedProfessor Matt ReedOngoing
Improving Care through Data Driven InnovationMultimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven InnovationWellcome Trust ISSF3Naz Lone/Professor Matt ReedProfessor Matt ReedOngoing