Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Cardiovascular

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status

ASPIRED	Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients	British Heart Foundation	Professor Matt Reed	Caroline Blackstock	Open to Recruitment
POC-ET	Point of Care Evaluation of high-sensitivity cardiac Troponin (POC-ET) study	British Heart Foundation	Professor Nick Mills	Fiona McCurrach	Open to Recruitment
TARGET-CTCA Trial	Troponin in Acute chest pain to Risk stratify and Guide EffecTive use of Computed Tomography Coronary Angiography	British Heart Foundation	Professor Nick Mills	Rachel O’Brien	Closed - in analysis stage

Stroke and Neurosurgery

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ATTEST2 Trial	Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis	Stroke Association & British Heart Foundation	Dr William Whitely	Allan MacRaild	Open to Recruitment
	BRAIN MATRIX	A BRitish feasibility study of molecular stratification and targeted therapy to optimize the clinical mAnagement of patieNts with glioMA by enhancing clinical ouTcomes, Reducing avoidable toXicity, improving management of post-operative residual & recurrent disease and improving survivorship	The Brain Tumour Charity and Genomics England	Dr Paul Brennan	Allan MacRaild	Open to Recruitment
BRAINED- TBI	BRAINED – TBI	Using Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain Injury	NIHR Brain Injury MedTech Co-operative Seedcorn Funding Competition	Dr Paul Brennan	Sarah Risbridger	Completing Follow Up
Can-SCAHn	Can-SCAHn	Selective neuroimaging for head-injured emergency patients who take anticoagulant medication.	Canadian Institutes of Health Research	Professor Matt Reed	Julia Grahamslaw	In Set Up
	CARE	Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma	NIHR	Mr Ioannis Fouyas	Allan MacRaild	Open to Recruitment
	DENS	Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar	NIHR HTA	Dr Paul Brennan/Professor Matt Reed	Anuka Boldbaatar	Open to Recruitment
ENRICH-AF	ENRICH-AF	EdoxabaN foR IntraCranial Hemorrhage survivors with Atrial Fibrillation	Daiichi Sankyo Company	Professor Rustam Al-Shahi Salman	Anuka Boldbaatar	Open to Recruitment
	IMPACT	International Post Market Product Surveillance Study of Intracranial Aneurysms Treated with an Endovascular Approach	STRYKER	Dr Jonny Downer	Allan MacRaild	Open to Recruitment
	INFERENCE	IdentificatioN oF biomarkErs foR Early diagNosis of CancEr	Innovate UK	Dr Paul Brennan	Sarah Risbridger	Completing Follow Up
	OPTIMAS	OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial	British Heart Foundation	Dr Fergus Dougal	Sarah Risbridger	Open to Recruitment
	PreSize	Real-World Performance Evaluation of PreSize Neurovascular Medical Software in a Clinical Setting	Oxford Heartbeat	Dr Jonny Downer	Sarah Risbridger	Open to Recruitment
	PROHIBIT-ICH	Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomised trial of home telemetry-guidedtreatment	Stroke Association	Neshika Samarasekera	Allan MacRaild	Completing Follow Up
	SEALANT	SEALANT: Safety and Effectiveness Analysis of stent assisted coiling with LVIS® Evo™ and HydroCoil® Embolic System in ANeurysm Treatment	Microvention	Dr Jonny Downer	Anuka Boldbaatar	Open to Recruitment
Shared Stroke Decisions	Shared Stroke Decisions	Development and implementation of Realistic Medicine for severe stroke through Shared Decision Making	Edinburgh and Lothian Health Foundation	Professor Gillian Mead	Sarah Risbridger	Completing Follow Up
	TREAT	Trenza Embolization Device for Intrasaccular Aneurysm Treatment	STRYKER	Dr Jonny Downer	Allan MacRaild	Open to Recruitment
	TRIDENT	Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial		Neshika Samarasekera	Allan MacRaild	Open to Recruitment
	PhEAST	Pharyngeal Electrical stimulation for Acute Stroke dysphagia Trial	National Institute of Health Research Health Technology Assessment program Devices supplied by Phagenesis Ltd	Richard O’Brien	Sarah Risbridger	Open to Recruitment
	Oceanic Stroke	Phase 3 study to investigate the efficacy and safety of the oral FXIa inhibitor asundexian (BAY 2433334) compared with placebo in participants after an acute non-cardioembolic ischemic stroke or high-risk TIA	Bayer AG	Neil Hunter	Sarah Risbridger	Open to Recruitment

Toxicology

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
POP2	POP2	A Randomised, Double-blind, Placebo-Controlled, Phase 2/3 Study with 2 Doses of Calmangafodipir in Increased Risk Patients Treated with N Acetylcysteine for Acetaminophen/Paracetamol Overdose	Egetis Therapeutics	Professor James Dear	Julia Grahamslaw/Caroline Blackstock	In Set Up
	HiSNAP	The HiSNAP Trial aims to test conventional (200mg/kg) versus higher (450mg/kg and 600mg/kg) doses of the drug N-Acetylcysteine (known as NAC) which is commonly used to treat the effects of paracetamol overdose	Chief Scientist Office	Professor James Dear	Anna Miell	In Set Up
POC-DILI	POC-DILI	The Point-of-care Assessment of Drug-Induced Liver Injury (POC-DILI) Study aims to develop blood testing for liver injury during the early stages of assessment of people who have taken a paracetamol overdose.	Medical Research Council (MRC)	Professor James Dear	Anna Miell	In Set Up
TIPSS	TIPSS	This trial aims to determine where in the body sulbutiamine/benfotiamine is converted to thiamine.	Medical Research Council (MRC) (Confidence in Concept Fund)	Professor Michael Eddleston	Anna Miell	Closed
Thiamine in CSF	Thiamine in CSF	This study aims to compare several forms of thiamine by testing the absorption into the blood and cerebrospinal fluid (CSF) at different time points after taking a dose		Professor Michael Eddleston	Anna Miell	Open to Recruitment

Blood Project Group

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	National Code Red Audit	The aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.	SNBTS	Professor Matt Reed	Professor Matt Reed	Open to Recruitment

Sepsis

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	EVIS	Early Vasopressors in Sepsis		Dr. Alasdair Corfield	Julia Grahamslaw &Fiona McCurrach	Open to Recruitment

Renal

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
AFiRM	AFiRM	Application of Functional Renal MRI to improve assessment of chronic kidney disease	National Institute for Health Research	Dr Neeraj Dhaun	Emily Godden	Open to Recruitment
	KRAKIL Study	Kidney Recovery after Acute Kidney Injury – Longitudinal study	Medical Research Council	Professor James Dear	Emily Godden	Open to Recruitment
OCT	OCT	Assessment of retinal vasculature using optical coherence tomography in health, hypertension & kidney disease		Dr Neeraj Dhaun	Emily Godden	Open to Recruitment

Trauma, Surgical and Orthopaedics

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	RELIEF	The Randomised Evaluation of early topical Lidocaine patches In Elderly patients admitted to hospital with rib Fractures (RELIEF): feasibility trial	North Bristol NHS Trust	Dr. Edward Carlton	Fiona McCurrach	Completing Follow Up

Paediatrics

Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status

FIDO	Validating clinical decision aids for the assessment and management of febrile infants presenting to emergency care in the UK and Ireland.	Royal College of Emergency Medicine Doctoral Fellowship	Dr Thomas Waterfield	Ashleigh Hegan	Closed to Recruitment
MAST	Pharmacological Management of Seizures post Traumatic Brain Injury.	NIHR	Dr Jay Shetty	Ashleigh Hegan	Open to recruitment
BACHb	Breathing Assistance in CHildren with bronchiolitis (BACHb): a group-sequential two-stratum multicentre open-label randomised clinical trial of respiratory support in infants with acute bronchiolitis	National Institute of Health Research	Dr David Armstrong	Caroline Blackstock	In Set Up

Other

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	CoSTED	Cessation Of Smoking Trial in the Emergency Department	Norfolk and Norwich University Hospitals NHS Foundation Trust (NNUH)	Professor Alasdair Gray	Anna Miell	Completing Follow Up

Innovation Studies

Biomarker

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	NOVEL2 Study	Collection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular Conditions	LumiraDX	Professor Alasdair Gray	Victoria Minnis	Open for Recruitment

Medical Wearable Device studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ASPIRED	Multi-centre open label randomised controlled trial of immediate enhanced ambulatory ECG monitoring versus standard monitoring in acute unexplained syncope patients	British Heart Foundation	Professor Matt Reed	Caroline Blackstock	Open to Recruitment

Data Projects

Data Science

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	Improving Multi-Morbidity Acute Care Using Data Analytics	SBRI: Improving Multi-Morbidity Acute Care Using Data Analytics	Health Innovation South East Scotland / Innovate UK	Naz Lone/Professor Matt Reed	Professor Matt Reed	Ongoing
	Improving Care through Data Driven Innovation	Multimorbidity and Emergency Healthcare Provision: Improving Care through Data Driven Innovation	Wellcome Trust ISSF3	Naz Lone/Professor Matt Reed	Professor Matt Reed	Ongoing

Current Research

Clinical Research

Innovation

Data projects