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Below are details of all current trials at EMERGE. Either click the area you are interested to see relevant studies or scroll through all our work.

If there is a study you’re interested in that isn’t listed here or you’d like to discuss a study with us then please get in touch. If you’re interested in a commercial collaboration and EMERGE evaluating something for you the please visit our Commercial Collaboration page.

Previous Cardiovascular Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
3CPO3CPO TrialA randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)NIHR HTAProfessor Alasdair GrayMoyra MassonClosed to Recruitment
Garfield-VTE StudyGlobal Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real worldBayer AGDr. Ann LockmanCaroline BlackstockClosed to Recruitment
HighSTEACSHighSTEACS is a randomised controlled trial, across 10 hospitals in NHS Lothian and NHS Greater Glasgow & Clyde, assessing patient outcomes before and after the implementation of high sensitivity Troponin assayBHFProfessor Alasdair GrayRachel O’BrienClosed to Recruitment
HighSTEACS BioresourceHighSTEACS BioresourceEvaluating the kinetics of cardiac biomarkers after ST-segment Elevation myocardial infarctionBHFProfessor Alasdair GrayRachel O’BrienClosed to Recruitment
IPED TrialRandomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncopeCHSS / BHFDr Matt ReedMia PaderangaClosed to Recruitment
IPED implementation studyReal-world clinical implementation of a smartphone-based event recorder in the ED for patients with palpitationn/aDr Matt ReedDr Julia CullenClosed to Recruitment
PRECISE-CTCAPRECISE-CTCA TrialtroPonin within the noRmal refEerenCe range to risk Stratify patients with acute chEst pain for Computed Tomography Coronary AngiographyBritish Heart FoundationDr Ken LeeRachel O’BrienClosed to Recruitment
PREFERPrefer in VTE Prevention of Thromboembolic Events – European Registry in Venous ThromboembolismEUSEMDr Matt ReedRachel O’Brien & Julia GrahamslawClosed to Recruitment
RAPID-CTCA TrialEvaluate role of early CT Coronary Angiography in the evaluation, intervention and outcome of patients presenting to the Emergency Department with suspected or confirmed Acute Coronary SyndromeBHFProfessor Alasdair GrayRachel O’BrienClosed to Recruitment
RATPACRandomised Assessment of Treatment using Panel Assay of Cardiac markersNIHR HTAProfessor Alasdair GrayJudy CoyleClosed to Recruitment
Relax 2 TrialA multicenter, randomised, double-blind, placebo-controlled phase IIIb study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients (CRLXA).NovartisProfessor Alasdair GrayJulia GrahamslawClosed to Recruitment
DAShEDThe DAShED (Diagnosis of Acute Aortic Syndrome in the ED) studyRCEMDr Rachel McLatchieRachel O’BrienClosed - submitted for publication.
ROSEROSERisk Stratification Of Syncope in the Emergency departmentCSODr Matt ReedDr Matt ReedClosed to Recruitment
ACUTEACUTEA mechanistic study of intravenous thiamine for acute heart failureMedical Research CouncilProfessor Michael Eddleston& Professor Matt ReedCaroline BlackstockClosed to Recruitment

Previous Stroke and Neurosurgery Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AHEADAHEADMonitoring anticoagulated patients who suffer head injuryNIHR Research for Patient Benefit Programme Dr Matt ReedJan GilchristClosed to Recruitment
AXIOMATIC-SSPAXIOMATIC-SSPAntithrombotic treatment with factor XIa inhibition to Optimize Management of Acute
Bristol-Myers SquibbDr Neil HunterMichelle CoakleyClosed to Recruitment
BRAINED StudyBRAINED StudyBlood samples will be assessed using infrared spectroscopy as part of a project looking at tumour biomarkers to ascertain whether people most at risk of having a brain tumour can be correctly identifiedDr Paul BrennanPolly BlackClosed to Recruitment
DASH TrialDASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.NIHRProfessor Rustam Al-Shahi SalmanMichelle CoakleyClosed to Recruitment
ETNAETNAEdinburgh Transient and Neurological attack: A Cohort StudyChief Scientist’s OfficeDr Will WhiteleyAllan MacRaildClosed to Recruitment
HeadOn StudyDelivery of digital cognitive behaviour therpy following concusion: HeadOn Feasibility StudyNIHR Brain Injury, MedTech Co-operative, Seedcorn Funding CompetitionAimun Jamjoom/Dr Matt ReedAlison GrantClosed to Recruitment
Laci-2Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to
British Heart FoundationProfessor Joanna Wardlaw Allan MacRaildClosed to Recruitment
LINCH-PINLothian study of INtraCerebral Haemorrhage Pathology, Imaging & Neurological outcomeUK Medical Research
Council and The Stroke Association
Dr Neshika SamarasekeraAllan MacRaildClosed to Recruitment
MRI in Acute StrokeMRI in Acute StrokeMRI in Acute Stroke TimingSpringboard Grant from North Bristol Trust and Dunhill Medical TrustAllan MacRaildClosed to Recruitment
PitSTOP To determine the prevalence of anterior pituitary gland dysfunction in traumatic brain injury in ScotlandDr John EmelifeonwuJulia GrahamslawClosed to Recruitment
PRECIOUSA clinical trial to look at PREvention of Complications to
European Union’s Horizon 2020 Research and Innovation
Professor Malcolm MacLeodJessica TeasdaleClosed to Recruitment
R4VADRates, Risks and Routes to Reduce Vascular DementiaStroke Association, Alzheimer’s Society, and British Heart
Foundation
Professor Joanna WardlawRachel SutherlandClosed to Recruitment
TICH-2 TrialTICH 2 TrialTranexamic Acid for Hyperacute Primary IntraCerebral HaemorrhageNIHRProfessor Rustam Al-Shahi SalmanAllan MacRaildClosed to Recruitment
TREAT-SVDEffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular
FuncTion in Small Vessel Diseases
European UnionDr Joanna WardlawDr Joanna WardlawClosed to Recruitment
TRIDENTTriple therapy prevention of Recurrent Intracerebral Disease EveNts TrialNational Health and Medical Research
Council (NHMRC) of Australia
Dr Neshika SamarasekeraAllan MacRaildClosed to Recruitment
ATTEST2 TrialAlteplase-Tenecteplase Trial Evaluation for Stroke ThrombolysisStroke Association & British Heart FoundationDr William WhitelyAllan MacRaildClosed to Recruitment
BRAINED- TBIBRAINED – TBIUsing Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain InjuryNIHR Brain Injury MedTech Co-operative Seedcorn Funding CompetitionDr Paul BrennanSarah RisbridgerClosed to Recruitment
CARECavernomas A Randomised Effectiveness (CARE) pilot trial, to address the
effectiveness of active treatment (with neurosurgery or stereotactic
radiosurgery) versus conservative management in people with symptomatic
brain cavernoma
NIHRMr Ioannis FouyasAllan MacRaildClosed to Recruitment
DENSDuration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collarNIHR HTADr Paul Brennan/Professor Matt ReedAnuka BoldbaatarClosed to Recruitment
INFERENCEIdentificatioN oF biomarkErs foR Early diagNosis of CancErInnovate UKDr Paul BrennanSarah RisbridgerClosed to Recruitment
OPTIMASOPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trialBritish Heart FoundationDr Fergus DougalSarah RisbridgerClosed to Recruitment
PROHIBIT-ICHPrevention Of Hypertensive Injury to the Brain by Intensive Treatment after
IntraCerebral Haemorrhage: a pilot randomised trial of home telemetry-guidedtreatment
Stroke AssociationNeshika SamarasekeraAllan MacRaildClosed to Recruitment
Shared Stroke DecisionsShared Stroke DecisionsDevelopment and implementation of Realistic Medicine for severe stroke through Shared Decision MakingEdinburgh and Lothian Health FoundationProfessor Gillian MeadSarah RisbridgerClosed to Recruitment
Can-SCAHnCan-SCAHnSelective neuroimaging for head-injured emergency patients who take anticoagulant medication.Canadian Institutes of Health ResearchProfessor Matt ReedJulia Grahamslaw

Previous Toxicology Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
MUPMinimal Unit Pricing Study (MUP)Measure the effect of Minimum Unit Pricing in Emergency Care SettingsNIHRDr Michelle OpenEmma MoattClosed to Recruitment
The POP TrialProfessor James DearAllan MacRaildClosed to Recruitment
SNAP TrialScottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning StudyProfessor James DearJudy CoyleClosed to Recruitment
IONAIONAIdentification Of Novel psychoActive substancesNIHR portfolioProfessor Michael EddlestonCaroline BlackstockClosed to Recruitment
MAPP2 StudyThe Markers and Paracetamol Poisoning Study 2Rosetrees Trust and Kidney Research UKProfessor James DearCaroline BlackstockClosed to Recruitment

Previous Blood Project Group Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
DEUCEIs Rotational Thromboelastometry (ROTEM) useful to detect Occult Coagulopathy in the Emergency Department?SNBTSDr Matt ReedAllan MacRaildClosed to Recruitment
E-FIT1E-FIT1 TrialRCT or fibrinogen concentrate within 45 minutes of admission to hospital in adult trauma patients with severe bleedingCSL BehringDr Matt ReedBernadette GallagherClosed to Recruitment
Halt-It TrialTranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trialNIHR HTADr Matt ReedJulia GrahamslawClosed to Recruitment
National Code Red AuditThe aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.SNBTSDr Matt ReedDr Matt ReedClosed to Recruitment
NoPac TrialTranexamic acid for the treatment of epistaxis: a randomised, double blind placebo controlled trialNIHR RfPBDr Matt ReedPolly BlackClosed to Recruitment
ROTEMRotem in EDSingle centre, prospective, observational Emergency Department based study of trauma patients who undergo ROTEM testingRCEMDr Matt ReedDr Matt ReedClosed to Recruitment
TRIGGERTRIGGERTransfusion in Gastrointestinal BleedingNHS Blood and Transplant Research and Development.Professor Alasdair GrayRachel O’BrienClosed to Recruitment
LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
BreathSpec-COVIDBreath analysis for the detection of COVID19 RCEM Dr Matt ReedRachel O’BrienClosed to Recruitment
CERAUnderstand the evolving and cumulative effects of working during the COVID-19 outbreak on the psychological health of those physicians working in the emergency care settings across the UKEmily Godden & Emma MoattClosed to Recruitment
COV_002 Vaccine TrialCOV_002 Vaccine TrialTo test a new vaccine, ChAdOx1 nCoV-19, against COVID-19 in healthy volunteersRachel O’BrienClosed to Recruitment
FALCONFacilitating AcceLerated Clinical evaluation Of Novel diagnostic tests for COVID-19NIHR, Asthma UK & British Lung FoundationDr. Rachel McLatchieCaroline BlackstockClosed to Recruitment
ISARIC4CClinical Characterisation Protocol for Severe Emerging
MRC, Wellcome Trust,
SPRINT-SARI NIHR Health Protection Research Unit (HPRU) in Respiratory Infection, HPRU
in Emerging and Zoonotic Infections
Dr Kenneth BaillieCaroline BlackstockClosed to Recruitment
PAN-EDPAN-EDEmily Godden & Emma MoattEmily Godden & Emma MoattClosed to Recruitment
PRIESTEvaluate current triage methods used to determine if a patient with suspected COVID-19 is to be admitted to hospital or not and whether or not they should be admitted to ICU/HDUPolly BlackClosed to Recruitment
RECOVERYRandomised Evaluation of COVID-19 TherapyDr. Alasdair GrayAllan MacRaildClosed to Recruitment
SIRENThe impact of detectable anti SARS-COV2 antibody on the incidence of COVID-19 in healthcare workersDr. Alasdair GrayAllan MacRaildClosed to Recruitment

Previous Trauma, Surgical and Orthopaedics Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
HU-FIX TrialA trial of operative versus conservative management in humeral shaft fracturesClosed to Recruitment
PROM OCTSThe creation and field testing of a new rib fracture specific patient reported outcome measure AOUK&I/NIHR HTA ORiFDr Matt ReedNicky FreemanClosed to Recruitment

Previous Sepsis Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
ABC SEPSISFeasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous
The Jon Moulton Charity Trust Professor Alasdair GrayJulia GrahamslawClosed to Recruitment
CVLA StudyCapillary and Venous Lactate Agreement – a pilot observational studyDr Dip DattaJulia GrahamslawClosed to Recruitment
ExPRES SEPSISTo derive a biomarker to allow the identification of patients with confirmed sepsis, and risk stratify patients at risk of developing severe sepsisProfessor Tim WalshJulia GrahamslawClosed to Recruitment
LAVAS StudyLactate, Arterial and Venous Agreement in SepsisDr Dip DattaJulia GrahamslawClosed to Recruitment
MIS-ABC SepsisMechanistic Inflammatory Sub-studyThe Royal College of Emergency MedicineDr. Jack CafferkeyJulia GrahamslawClosed to Recruitment

Previous Paediatric Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
EcLiPSEEcLiPSE TrialComparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adultsNIHR HTADr Jen BrowningJulia GrahamslawClosed to Recruitment
BRONCHSTART2The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations, a Multi Centre Prospective Observational Cohort Study Extension.PERUKI and RESCEUThomas WilliamsAshleigh HeganClosed to Recruitment
Button BatteriesButton BatteriesThe unintentional ingestion, inhalation or insertion of button batteries in children requiring removal or attempted removalSir Peter Tizard Research BursaryDr Suvradeep BasuAshleigh HeganCompleting Follow Up
INFORMPoint of Care device for the detection of Influenza A/B, Respiratory Syncytial Virus (RSV) & SARS-COV-2 VirusLumiraDXDr. Jen BrowningCaroline BlackstockClosed to Recruitment
MAGNETICA prospective surveillance study of magnetic ingestion in childrenN/AProfessor Nigel HallAshleigh HeganClosed to Recruitment

Other Previous Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
Time and MotionTo explore the time taken for research nurses to recruit patients in an Emergency Department (ED) settingn/aRachel O’Brien& Polly BlackRachel O’Brien& Polly BlackClosed to Recruitment
3MG TrialA randomised trial of intravenous or nebulised magnesium sulphate versus placebo for acute severe asthmaNIHR HTAProfessor Alasdair GrayMoyra MassonClosed to Recruitment
4AT StudyTo determine the diagnostic accuracy of the 4AT for delirium versus the reference standard of a DSM-IV diagnosisClosed to Recruitment
EURODEMThe European Dyspnoea survey in the Emergency DepartmentsEUSEMDr Matt ReedRachel O’BrienClosed to Recruitment
POEMAssess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limbClosed to Recruitment
First 'First Responder'First “First Responder” StudyProvide the first in-depth look into the experience of the OHCA bystander responderJoel SymondsClosed to Recruitment
ENCEPH UK StudyENCEPH UK StudyTo produce a predictive tool for HSV encephalitis based on the early clinical features, by comparing the clinical features of those with and without HSV encephalitisNIHR Programme for Applied ResearchDr Matt ReedJulia GrahamslawClosed to Recruitment
COPSDr Frank PriorDr Frank PriorClosed to Recruitment
The Prior StudyPlot the Membrane Osmotic Pressure (MOP) and Mean arterial pressure (MAP) of healthy participants onto a chart that has been created from previous workDr Frank PriorDr Frank PriorClosed to Recruitment
The STRETCHED StudySTRETCHEDSubsequent healthcare resource utilisation in patients discharge from Emergency Care after a presentation with acute severe headache – a feasibility study with hypothesis generating mixed methodsanalysisProfessor Matt ReedAlison GrantClosed to Recruitment

Innovation Studies

Previous Biomarker Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
AKI in LC StudyA study of AKI in hospital patientsFiona GiffordCaroline BlackstockClosed to Recruitment
EHA StudyA diagnostic screening study for hereditary angioedema in the EDCentrogeneDr Matt ReedFiona McCurrachClosed to Recruitment
EMBOL1 StudyA Performance Evaluation of The LumiraDX Point of Care D-DIMER LumiraDXProfessor Alasdair GrayCaroline BlackstockClosed to Recruitment
NOVEL StudyCollection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular ConditionsLumiraDXProfessor Alasdair GrayAnna MiellClosed to Recruitment
REACT StudyA Performance Evaluation of The LumiraDX Point of Care CRP Assay LumiraDXProfessor Alasdair GrayCaroline BlackstockClosed to Recruitment
TPTIHTPTIHTo establish genetic associations between patients with thiazide-induced hyponatraemia and patients taking a thiazide who did not develop hyponatraemiaAnn LockmanCaroline BlackstockClosed to Recruitment

Previous Medical Wearable Device Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus
PATCH-EDDiagnostic yield of an ambulatory patch monitor in Emergency Department syncope patients unexplained after Emergency Department evaluationChest, Heart and Stroke ScotlandDr Matt ReedKirsty SimpsonClosed to Recruitment
RAMPP trialInvestigate the use of a pleural vent (rocket) versus standard care in patients with Primary Spontaneous Pnuemothorax in a randomised controlled trialMedical Research Council and the National Institute for Health Research (UK)Dr Marie-Clare HarrisMia PaderangaClosed to Recruitment

Data Projects

Previous Data Science Studies

LogoTitleDescriptionFunding BodyChief/Principal InvestigatorKey ContactStatus