Previous Cardiovascular Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
3CPO	3CPO Trial	A randomised controlled trial of continuous positive airway pressure (CPAP) vs non invasive ventilation (NIV) vs standard therapy for acute pulmonary odema (ACPO)	NIHR HTA	Professor Alasdair Gray	Moyra Masson	Closed to Recruitment
	Garfield-VTE Study	Global Anticoagulant Registry in the FIELD observing treatment and outcomes in patients with treated acute Venous Thromboembolic Events in the real world	Bayer AG	Dr. Ann Lockman	Caroline Blackstock	Closed to Recruitment
	HighSTEACS	HighSTEACS is a randomised controlled trial, across 10 hospitals in NHS Lothian and NHS Greater Glasgow & Clyde, assessing patient outcomes before and after the implementation of high sensitivity Troponin assay	BHF	Professor Alasdair Gray	Rachel O’Brien	Closed to Recruitment
HighSTEACS Bioresource	HighSTEACS Bioresource	Evaluating the kinetics of cardiac biomarkers after ST-segment Elevation myocardial infarction	BHF	Professor Alasdair Gray	Rachel O’Brien	Closed to Recruitment
	IPED Trial	Randomised controlled Trial using smart phone based event recorder technology versus standard care in palpatations or pre-syncope	CHSS / BHF	Dr Matt Reed	Mia Paderanga	Closed to Recruitment
	IPED implementation study	Real-world clinical implementation of a smartphone-based event recorder in the ED for patients with palpitation	n/a	Dr Matt Reed	Dr Julia Cullen	Closed to Recruitment
PRECISE-CTCA	PRECISE-CTCA Trial	troPonin within the noRmal refEerenCe range to risk Stratify patients with acute chEst pain for Computed Tomography Coronary Angiography	British Heart Foundation	Dr Ken Lee	Rachel O’Brien	Closed to Recruitment
	PREFER	Prefer in VTE Prevention of Thromboembolic Events – European Registry in Venous Thromboembolism	EUSEM	Dr Matt Reed	Rachel O’Brien & Julia Grahamslaw	Closed to Recruitment
	RAPID-CTCA Trial	Evaluate role of early CT Coronary Angiography in the evaluation, intervention and outcome of patients presenting to the Emergency Department with suspected or confirmed Acute Coronary Syndrome	BHF	Professor Alasdair Gray	Rachel O’Brien	Closed to Recruitment
	RATPAC	Randomised Assessment of Treatment using Panel Assay of Cardiac markers	NIHR HTA	Professor Alasdair Gray	Judy Coyle	Closed to Recruitment
	Relax 2 Trial	A multicenter, randomised, double-blind, placebo-controlled phase IIIb study to evaluate the efficacy, safety and tolerability of Serelaxin when added to standard therapy in acute heart failure patients (CRLXA).	Novartis	Professor Alasdair Gray	Julia Grahamslaw	Closed to Recruitment
	DAShED	The DAShED (Diagnosis of Acute Aortic Syndrome in the ED) study	RCEM	Dr Rachel McLatchie	Rachel O’Brien	Closed - submitted for publication.
ROSE	ROSE	Risk Stratification Of Syncope in the Emergency department	CSO	Dr Matt Reed	Dr Matt Reed	Closed to Recruitment
ACUTE	ACUTE	A mechanistic study of intravenous thiamine for acute heart failure	Medical Research Council	Professor Michael Eddleston& Professor Matt Reed	Caroline Blackstock	Closed to Recruitment

Previous Stroke and Neurosurgery Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
AHEAD	AHEAD	Monitoring anticoagulated patients who suffer head injury	NIHR Research for Patient Benefit Programme	Dr Matt Reed	Jan Gilchrist	Closed to Recruitment
AXIOMATIC-SSP	AXIOMATIC-SSP	Antithrombotic treatment with factor XIa inhibition to Optimize Management of Acute	Bristol-Myers Squibb	Dr Neil Hunter	Michelle Coakley	Closed to Recruitment
BRAINED Study	BRAINED Study	Blood samples will be assessed using infrared spectroscopy as part of a project looking at tumour biomarkers to ascertain whether people most at risk of having a brain tumour can be correctly identified		Dr Paul Brennan	Polly Black	Closed to Recruitment
	DASH Trial	DASH is a randomised clinical trial investigating a treatment to reverse the effects of blood-thinning medications.	NIHR	Professor Rustam Al-Shahi Salman	Michelle Coakley	Closed to Recruitment
ETNA	ETNA	Edinburgh Transient and Neurological attack: A Cohort Study	Chief Scientist’s Office	Dr Will Whiteley	Allan MacRaild	Closed to Recruitment
	HeadOn Study	Delivery of digital cognitive behaviour therpy following concusion: HeadOn Feasibility Study	NIHR Brain Injury, MedTech Co-operative, Seedcorn Funding Competition	Aimun Jamjoom/Dr Matt Reed	Alison Grant	Closed to Recruitment
	Laci-2	Assessment of safety and efficacy of cilostazol and isosorbide mononitrate to	British Heart Foundation	Professor Joanna Wardlaw	Allan MacRaild	Closed to Recruitment
	LINCH-PIN	Lothian study of INtraCerebral Haemorrhage Pathology, Imaging & Neurological outcome	UK Medical Research Council and The Stroke Association	Dr Neshika Samarasekera	Allan MacRaild	Closed to Recruitment
MRI in Acute Stroke	MRI in Acute Stroke	MRI in Acute Stroke Timing	Springboard Grant from North Bristol Trust and Dunhill Medical Trust		Allan MacRaild	Closed to Recruitment
	PitSTOP	To determine the prevalence of anterior pituitary gland dysfunction in traumatic brain injury in Scotland		Dr John Emelifeonwu	Julia Grahamslaw	Closed to Recruitment
	PRECIOUS	A clinical trial to look at PREvention of Complications to	European Union’s Horizon 2020 Research and Innovation	Professor Malcolm MacLeod	Jessica Teasdale	Closed to Recruitment
	R4VAD	Rates, Risks and Routes to Reduce Vascular Dementia	Stroke Association, Alzheimer’s Society, and British Heart Foundation	Professor Joanna Wardlaw	Rachel Sutherland	Closed to Recruitment
TICH-2 Trial	TICH 2 Trial	Tranexamic Acid for Hyperacute Primary IntraCerebral Haemorrhage	NIHR	Professor Rustam Al-Shahi Salman	Allan MacRaild	Closed to Recruitment
	TREAT-SVD	EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases	European Union	Dr Joanna Wardlaw	Dr Joanna Wardlaw	Closed to Recruitment
	TRIDENT	Triple therapy prevention of Recurrent Intracerebral Disease EveNts Trial	National Health and Medical Research Council (NHMRC) of Australia	Dr Neshika Samarasekera	Allan MacRaild	Closed to Recruitment
	ATTEST2 Trial	Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis	Stroke Association & British Heart Foundation	Dr William Whitely	Allan MacRaild	Closed to Recruitment
BRAINED- TBI	BRAINED – TBI	Using Fourier Transform Infrared Spectrotroscopy for Earlier Diagnosis and Rapid Stratification of Patients with a Traumatic Brain Injury	NIHR Brain Injury MedTech Co-operative Seedcorn Funding Competition	Dr Paul Brennan	Sarah Risbridger	Closed to Recruitment
	CARE	Cavernomas A Randomised Effectiveness (CARE) pilot trial, to address the effectiveness of active treatment (with neurosurgery or stereotactic radiosurgery) versus conservative management in people with symptomatic brain cavernoma	NIHR	Mr Ioannis Fouyas	Allan MacRaild	Closed to Recruitment
	DENS	Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar	NIHR HTA	Dr Paul Brennan/Professor Matt Reed	Anuka Boldbaatar	Closed to Recruitment
	INFERENCE	IdentificatioN oF biomarkErs foR Early diagNosis of CancEr	Innovate UK	Dr Paul Brennan	Sarah Risbridger	Closed to Recruitment
	OPTIMAS	OPtimal TIMing of Anticoagulation after acute ischaemic Stroke: a randomised controlled trial	British Heart Foundation	Dr Fergus Dougal	Sarah Risbridger	Closed to Recruitment
	PROHIBIT-ICH	Prevention Of Hypertensive Injury to the Brain by Intensive Treatment after IntraCerebral Haemorrhage: a pilot randomised trial of home telemetry-guidedtreatment	Stroke Association	Neshika Samarasekera	Allan MacRaild	Closed to Recruitment
Shared Stroke Decisions	Shared Stroke Decisions	Development and implementation of Realistic Medicine for severe stroke through Shared Decision Making	Edinburgh and Lothian Health Foundation	Professor Gillian Mead	Sarah Risbridger	Closed to Recruitment
Can-SCAHn	Can-SCAHn	Selective neuroimaging for head-injured emergency patients who take anticoagulant medication.	Canadian Institutes of Health Research	Professor Matt Reed	Julia Grahamslaw

Previous Toxicology Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
MUP	Minimal Unit Pricing Study (MUP)	Measure the effect of Minimum Unit Pricing in Emergency Care Settings	NIHR	Dr Michelle Open	Emma Moatt	Closed to Recruitment
	The POP Trial			Professor James Dear	Allan MacRaild	Closed to Recruitment
	SNAP Trial	Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study		Professor James Dear	Judy Coyle	Closed to Recruitment
IONA	IONA	Identification Of Novel psychoActive substances	NIHR portfolio	Professor Michael Eddleston	Caroline Blackstock	Closed to Recruitment
	MAPP2 Study	The Markers and Paracetamol Poisoning Study 2	Rosetrees Trust and Kidney Research UK	Professor James Dear	Caroline Blackstock	Closed to Recruitment

Previous Blood Project Group Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	DEUCE	Is Rotational Thromboelastometry (ROTEM) useful to detect Occult Coagulopathy in the Emergency Department?	SNBTS	Dr Matt Reed	Allan MacRaild	Closed to Recruitment
E-FIT1	E-FIT1 Trial	RCT or fibrinogen concentrate within 45 minutes of admission to hospital in adult trauma patients with severe bleeding	CSL Behring	Dr Matt Reed	Bernadette Gallagher	Closed to Recruitment
	Halt-It Trial	Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial	NIHR HTA	Dr Matt Reed	Julia Grahamslaw	Closed to Recruitment
	National Code Red Audit	The aim of this audit is to monitor and optimise the transfusion support given to patients following major trauma in Scotland.	SNBTS	Dr Matt Reed	Dr Matt Reed	Closed to Recruitment
	NoPac Trial	Tranexamic acid for the treatment of epistaxis: a randomised, double blind placebo controlled trial	NIHR RfPB	Dr Matt Reed	Polly Black	Closed to Recruitment
ROTEM	Rotem in ED	Single centre, prospective, observational Emergency Department based study of trauma patients who undergo ROTEM testing	RCEM	Dr Matt Reed	Dr Matt Reed	Closed to Recruitment
TRIGGER	TRIGGER	Transfusion in Gastrointestinal Bleeding	NHS Blood and Transplant Research and Development.	Professor Alasdair Gray	Rachel O’Brien	Closed to Recruitment

Previous Trauma, Surgical and Orthopaedics Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	HU-FIX Trial	A trial of operative versus conservative management in humeral shaft fractures				Closed to Recruitment
	PROM OCTS	The creation and field testing of a new rib fracture specific patient reported outcome measure	AOUK&I/NIHR HTA ORiF	Dr Matt Reed	Nicky Freeman	Closed to Recruitment

Previous Sepsis Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	ABC SEPSIS	Feasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous	The Jon Moulton Charity Trust	Professor Alasdair Gray	Julia Grahamslaw	Closed to Recruitment
	CVLA Study	Capillary and Venous Lactate Agreement – a pilot observational study		Dr Dip Datta	Julia Grahamslaw	Closed to Recruitment
	ExPRES SEPSIS	To derive a biomarker to allow the identification of patients with confirmed sepsis, and risk stratify patients at risk of developing severe sepsis		Professor Tim Walsh	Julia Grahamslaw	Closed to Recruitment
	LAVAS Study	Lactate, Arterial and Venous Agreement in Sepsis		Dr Dip Datta	Julia Grahamslaw	Closed to Recruitment
	MIS-ABC Sepsis	Mechanistic Inflammatory Sub-study	The Royal College of Emergency Medicine	Dr. Jack Cafferkey	Julia Grahamslaw	Closed to Recruitment

Previous Paediatric Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
EcLiPSE	EcLiPSE Trial	Comparing intravenous levetiracetam to intravenous phenytoin for the treatment of convulsive status epilepticus (CSE) in children, young people and young adults	NIHR HTA	Dr Jen Browning	Julia Grahamslaw	Closed to Recruitment
	BRONCHSTART2	The Impact of the COVID-19 Pandemic on the Timing, Age and Severity of Respiratory Syncytial Virus (RSV) Emergency Presentations, a Multi Centre Prospective Observational Cohort Study Extension.	PERUKI and RESCEU	Thomas Williams	Ashleigh Hegan	Closed to Recruitment
Button Batteries	Button Batteries	The unintentional ingestion, inhalation or insertion of button batteries in children requiring removal or attempted removal	Sir Peter Tizard Research Bursary	Dr Suvradeep Basu	Ashleigh Hegan	Completing Follow Up
	INFORM	Point of Care device for the detection of Influenza A/B, Respiratory Syncytial Virus (RSV) & SARS-COV-2 Virus	LumiraDX	Dr. Jen Browning	Caroline Blackstock	Closed to Recruitment
	MAGNETIC	A prospective surveillance study of magnetic ingestion in children	N/A	Professor Nigel Hall	Ashleigh Hegan	Closed to Recruitment

Other Previous Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	Time and Motion	To explore the time taken for research nurses to recruit patients in an Emergency Department (ED) setting	n/a	Rachel O’Brien& Polly Black	Rachel O’Brien& Polly Black	Closed to Recruitment
	3MG Trial	A randomised trial of intravenous or nebulised magnesium sulphate versus placebo for acute severe asthma	NIHR HTA	Professor Alasdair Gray	Moyra Masson	Closed to Recruitment
	4AT Study	To determine the diagnostic accuracy of the 4AT for delirium versus the reference standard of a DSM-IV diagnosis				Closed to Recruitment
	EURODEM	The European Dyspnoea survey in the Emergency Departments	EUSEM	Dr Matt Reed	Rachel O’Brien	Closed to Recruitment
	POEM	Assess the adequacy of pain management in patients presenting to the ED with confirmed long bone fracture and/or dislocation isolated to a proximal or distal limb				Closed to Recruitment
First 'First Responder'	First “First Responder” Study	Provide the first in-depth look into the experience of the OHCA bystander responder		Joel Symonds		Closed to Recruitment
ENCEPH UK Study	ENCEPH UK Study	To produce a predictive tool for HSV encephalitis based on the early clinical features, by comparing the clinical features of those with and without HSV encephalitis	NIHR Programme for Applied Research	Dr Matt Reed	Julia Grahamslaw	Closed to Recruitment
	COPS			Dr Frank Prior	Dr Frank Prior	Closed to Recruitment
	The Prior Study	Plot the Membrane Osmotic Pressure (MOP) and Mean arterial pressure (MAP) of healthy participants onto a chart that has been created from previous work		Dr Frank Prior	Dr Frank Prior	Closed to Recruitment
The STRETCHED Study	STRETCHED	Subsequent healthcare resource utilisation in patients discharge from Emergency Care after a presentation with acute severe headache – a feasibility study with hypothesis generating mixed methodsanalysis		Professor Matt Reed	Alison Grant	Closed to Recruitment

Innovation Studies

Previous Biomarker Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	AKI in LC Study	A study of AKI in hospital patients		Fiona Gifford	Caroline Blackstock	Closed to Recruitment
	EHA Study	A diagnostic screening study for hereditary angioedema in the ED	Centrogene	Dr Matt Reed	Fiona McCurrach	Closed to Recruitment
	EMBOL1 Study	A Performance Evaluation of The LumiraDX Point of Care D-DIMER	LumiraDX	Professor Alasdair Gray	Caroline Blackstock	Closed to Recruitment
	NOVEL Study	Collection of Venous and Capillary Blood Samples for the Development of New Diagnostic Devices for Cardiovascular Conditions	LumiraDX	Professor Alasdair Gray	Anna Miell	Closed to Recruitment
	REACT Study	A Performance Evaluation of The LumiraDX Point of Care CRP Assay	LumiraDX	Professor Alasdair Gray	Caroline Blackstock	Closed to Recruitment
TPTIH	TPTIH	To establish genetic associations between patients with thiazide-induced hyponatraemia and patients taking a thiazide who did not develop hyponatraemia		Ann Lockman	Caroline Blackstock	Closed to Recruitment

Previous Medical Wearable Device Studies

Logo	Title	Description	Funding Body	Chief/Principal Investigator	Key Contact	Status
	PATCH-ED	Diagnostic yield of an ambulatory patch monitor in Emergency Department syncope patients unexplained after Emergency Department evaluation	Chest, Heart and Stroke Scotland	Dr Matt Reed	Kirsty Simpson	Closed to Recruitment
	RAMPP trial	Investigate the use of a pleural vent (rocket) versus standard care in patients with Primary Spontaneous Pnuemothorax in a randomised controlled trial	Medical Research Council and the National Institute for Health Research (UK)	Dr Marie-Clare Harris	Mia Paderanga	Closed to Recruitment

Data Projects

Previous Data Science Studies