Halt-It Trial
HALT-IT trial, Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial
Aim
The HALT‐IT trial will determine the effect of early administration of TXA on mortality, morbidity (re‐bleeding, non‐fatal vascular events), blood transfusion, surgical intervention and health status in patients with acute gastrointestinal bleeding.
Trial Design
A pragmatic, randomised, double blind, placebo controlled trial among 8,000 patients with significant gastrointestinal bleeding.
Eligibility criteria
Patients with significant GI bleeds in whom the use of tranexamic acid is neither indicated nor contraindicated
Chief Investigator
Professor Iain Roberts (LSHTM)
Local PI
Dr Matt Reed (RIE)
Research Team
Dr Nick Church
Dr James Dear
Dr Kallirroi Kefala
Julia Grahamslaw – local EMeRGE study lead
ED research nurses