Toggle menu

Halt-It Trial

Start date:
August 2014
End date:
November 2016
Co-ordinated by:
London School of Hygiene and Tropical Medicine
Main trial site:
http://haltit.lshtm.ac.uk

HALT-IT trial, Tranexamic acid for the treatment of gastrointestinal haemorrhage: an international randomised, double blind placebo controlled trial

 

Aim

The HALT‐IT trial will determine the effect of early administration of TXA on mortality, morbidity (re‐bleeding, non‐fatal vascular events), blood transfusion, surgical intervention and health status in patients with acute gastrointestinal bleeding.

Trial Design

A pragmatic, randomised, double blind, placebo controlled trial among 8,000 patients with significant gastrointestinal bleeding.

Eligibility criteria

Patients with significant GI bleeds in whom the use of tranexamic acid is neither indicated nor contraindicated

Chief Investigator

Professor Iain Roberts (LSHTM)

Local PI

Dr Matt Reed (RIE)

Research Team

Dr Nick Church
Dr James Dear
Dr Kallirroi Kefala
Julia Grahamslaw – local EMeRGE study lead
ED research nurses

Local PI

Dr Matt Reed

Director of EMERGE, Consultant, NRS Career Research Fellow & Honorary Reader in Emergency Medicine

Research Team

Julia Grahamslaw

Lead Research Nurse

Bernadette Gallagher

Senior Research Nurse

More EMERGE Trials

Prospective multicentre observational study conducted over one calendar month in 2019, with the aim of describing the epidemiology of non-trauma related headache in adults presenting to emergency departments including investigations, treatments and outcome.

This will include adult patients presenting to the ED with non-trauma-related headache as their primary complaint.

Read more

HEAD Study

Evaluating the role of early CT Coronary Angiography on patients with suspected or confirmed Acute Coronary Syndrome.

Read more

RAPID-CTCA Trial

Evaluating the role of early CT Coronary Angiography

Diagnostics devices play an important part in the clinical assessment of a patient’s health and treatment. The purpose of the study is the evaluation of a new diagnostic platform developed by LumiraDx. The evaluation is focused around various biomarkers useful in the emergency settings.

Read more

NOVEL Study

Collection of venous and capillary blood samples for the evaluation of new diagnostic devices for cardiovascular conditions