Tranexamic Acid for Hyperacute Primary IntraCerebral Haemorrhage
To assess whether tranexamic acid is safe and reduces death and dependency after hyperacute (within 8 hours of onset) spontaneous intracerebral haemorrhage.
A phase III prospective pragmatic double blind randomised placebo controlled trial
Dr Nikola Sprigg (Medical expert) Clinical Associate Professor, University of Nottingham
Professor Rustam Al-Shahi Salman, Professor of clinical neurology, University of Edinburgh & NHS Lothian
Dr Matt Reed is the local contact for recruitment of ED patients into the study.
Patients who present to the ED within 8 hours of acute spontaneous intracerebral haemorrhagic stroke.
For more information please refer to main trial website
The study with PP100-01 in combination with NAC is designed to determine safety and tolerability of PP100-01 when co-administered with NAC as compared to the 12-hr NAC treatment regime for patients that come to the hospital after an overdose of paracetamol/acetaminophen.
A Randomised Open Label Exploratory, Safety and Tolerability Study with PP100-01 in Patients Treated with the 12-hour Regimen of N-Acetylcysteine for Paracetamol/Acetaminophen Overdose
This is a study looking at incidence and risk factors for poor ankle functional recovery, and the development and progression of post-traumatic ankle osteoarthritis after significant ankle ligament injury.
SALI study - Significant Ankle Ligament Injury